How SeaBD 75 CBD Reduces Stress and Supports The Immune System.

Stress wreaks havoc on the body in many complex ways. Inflammation is often a primary manifestation of how stress impedes upon the body’s functioning and overall balance. Inflammation can result from oxidative stress, compromised digestion and therefore absorption and assimilation of vital nutrients the body requires to function optimally. Inflammation often leads to compromised mood and overall immunity (1).

SeaBD 75 strengthens immunity by promoting a healthy immune response in the body to stress and inflammation (which are the culprits to compromising the body’s immune system). With all natural, never toxic or additive ingredients, SeaBD 75 helps to address underlying contributing factors to inflammation and thereby compromised immunity.

Phytocannabinoids. CBD, or Cannabidiol is a Phytocannabinoid- in addition to THC (the psychoactive constituent in Marijuana). Phytocannabinoids are cannabinoids derived from plants that mimic many of the biological actions of our own body processes, helping it to achieve balance and overall optimal functioning particularly with regards to immunity. These phytocannabinoids (CBD, THC) interact with natural receptors that we have in our bodies, called Cannabinoid Receptors (CB1/Cannabinoid Receptor 1) and (CB2/Cannabinoid Receptor 2), in order to stimulate responses in our body that encourage balance. CB1 and CB2 receptors inhibit the pro-inflammatory and pro-oxidative activities especially in the colon- having strong implications in terms of immune health (2).

In addition to cannabinoids, our bodies also comprise of endocannabinoids (Anandamide or AEA) and (2- Arachidonylglycerol or 2-AG), natural endogenous lipids that help to activate the body’s cannabinoid receptors, also helping to reach optimal balance. Endocannabinoids, as well as cannabinoid receptors make up the body’s Endocannabinoid System. This system ensures balance amongst our body’s physiological processes, by eliciting chemical responses from phytocannabinoids (CBD, THC) as well as from our natural endocannabinoids (AEA, 2-AG) from interaction with cannabinoid receptors (CB1, CB2). The Endocannabinoid System has a role in regulating inflammation, immunity, digestion, pain, appetite, memory and mood.

Our body has natural cannabinoid receptors that are located throughout the body: Cannabinoid 1 Receptors are primarily located and expressed in the brain and nervous system, in addition to the liver, lungs and kidneys. Our natural endocannabinoid AEA as well as cannabinoids consumed, bind primarily with this receptor (CB1) offering relief from symptoms relative to pain, inflammation, compromised digestion, and even mood. Cannabinoid 2 Receptors are located primarily in the immune system, GI tract and spleen; they play a central role in modulating our immune response as well as addressing inflammation. CB2 receptors bind most effectively with 2-AG; Our natural endocannabinoids, as well as cannabinoids consumed, bind primarily with this receptor (CB2), offering relief of inflammation from stress, compromised digestion as well as pain, and help to improve overall immunity. Specifically, CB2 receptors reduce NOS activity, reduces IL-6 expression, TNF-α and IL-1β expression, as well as modulates and reduces the activity of TNF-α and COX-2 in the context of LPS-induced inflammation (2).

Optimizing and balancing our body’s natural Endocannabinoid System with SeaBD 75 has many implications in terms of immune health as it modulates the body’s overall stress response as well as strongly reduces inflammation. Recent research suggests that cannabinoids may elicit antidepressant and anti-anxiety properties as they help to improve balance amongst this system in the body.

Further Stress Reduction Implications

Our natural AEA endocannabinoids have a strong affinity for CB1 receptors, which are most abundant in the brain regions relative to our mood as well as how we handle stress (the prefrontal cortex, hippocampus, amygdala, hypothalamus, and forebrain monoaminergic circuits). CB1 Receptors elicit stress reduction and modulating effects as they normalize the hyperactivity of hypothalamic-pituitary-adrenal axis (HPA). Furthermore, CB1 Receptor activation also interacts with Serotonin 5-HT 1A receptors, regulation of monamine activity, GABA and glutamate neurons, similar to the effects of antidepressants. If we do not have enough natural endocannabinoids, supplementing with Phytocannabinoids can help to restore this balance as they help the ECS to function properly. Endocannabinoids are made as well as degraded in the body, particularly during stress this degradation process happens more rapidly. Stress also impedes upon the functioning and balance of the Endocannabinoid System. Suboptimal functioning of this system and deficiencies in endocannabinoids in this natural body system contributes to a compromised stress response, in addition to increased inflammation and overall a reduction in immune health.

SeaBD 75 comprises a unique blend of natural, organic yet effective ingredients for immune health in addition to the potent and clean phytocannabinoids.

A closer look at the subsequent ingredients in SeaBD 75: addressing immunity, inflammation and the stress response:

The immune stress blend comprises of:

Organic Virgin Sea Buckthorn Oil is a red-orange oil, derived from sea buckthorn plants with strong immune-boosting properties. The high flavonoid Vitamin C content of Sea Buckthorn oil is a notable component with its high potency antioxidant effects- helping to counteract oxidative stress in the body- and the damaging effects of such- resulting in inflammation and compromised immunity. The effects of Organic Virgin Sea Buckthorn Oil include cytokine production and modulation, signaling pathways, and overall immunity (3).

Essential Oil Blend

Organic Essential Oil Blend (Bergamont, Ginger, Lavendar, Cinnamon bark, Hellichyrsum, Eucalyptus Rad, Clary sage, Lavender, Lemon

Bergamont. Bergamont has antiseptic properties as well as antimicrobial activity (4).

Ginger. Ginger has antiviral, anti-inflammatory and antioxidant effects (5).

Cinnamon bark. Cinnamon bark has been found to have anti-inflammatory as well as calming properties and has been found to enhance immunity (6).

Hellichyrsum. This essential oil has been found to have strong anti-inflammatory, antioxidant and antimicrobial properties, as well as improving immunity (7).  In fact it’s sesquiterpene, Chloroquine is greatly effective in combating viral infections.

Eucalyptus Rad. Eucalyptus has been shown to have antibacterial, antiviral, antifungal and anti-inflammatory effects in the body, thereby strongly supporting immunity (8).

Clary Sage. The literature available on clary sage essential oil suggests it is effective in controlling cortisol levels along with its antimicrobial activity (9) (10).

Lavender. Lavender has been particularly known to be particularly helpful in terms of the stress response- helping to reduce anxiety levels. Additionally, lavender has also promising anti-inflammatory effects further aiding in immunity (11).

Lemon. Lemon has shown to have antioxidant as well as anti-inflammatory properties, contributing to immune health (12).

In conjunction with the strong yet clean potency of phytocannabinoids- these above ingredients have profound effects on immunity, inflammation, as well as help to modulate the stress response- further contributing to enhanced immune health.

References:

1.  Iddir M. et al. (2020). Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during COVID-19 Crisis. Nutrients, 12.

2.      Dinu R. A et al. (2020). Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis. Cells, 9.

3.      Seyedebrahimi S. (2021). Immune system and Olive Oil. Olives and Olive Oil in Health and Disease Prevention, 389-398.

4.      Cosention M. et al (2014). The Essential Oil of Bergamot Stimulates Reactive Oxygen Species Production in Human Polymorphonuclear Leukocytes. Phytotherapy Research.

5.  Dissanayake K. G et al. (2020). A Review on Medicinal Uses of Zingiber officinale (Ginger). International Journal of Health and Sciences Research, 10.

6.      Ose R. et al (2019). Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models. Clinical and Experimental Allergy, 1.

7. Taşkın T. (2020). The in vitro and in vivo investigation of biological activities and phenolic analysis of Helichrysum plicatum subsp. Plicatum. Brazilian Journal of Pharmaceutical Sciences, 56.

8. Insights into Eucalyptus genus chemical constituents, biological activities and health-promoting effects. Trends in Food Science & Technology, 91.

9. M. Sienkiewicz et al. (2015). The effect of clary sage oil on staphylococci responsible for wound infections. Postepy Dermatol Alergol, 32, 1.

10. K.B. Lee et al. (2014). Changes in 5-hydroxytryptamine and cortisol plasma levels in menopausal women after inhalation of clary sage oil. Phytother Res, 28

11. Cardia G. F et al. (2018). Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response. Complementary and Alternative Therapies for Inflammatory Diseases.

12. Hoseinifar S et al. (2020). Dietary supplementation of lemon verbena (Aloysia citrodora) improved immunity, immune-related genes expression and antioxidant enzymes in rainbow trout (Oncorrhyncus mykiss). Fish & Shellfish Immunology, 99