SeaBD 75 CBD Digestive Implications From Stress

Stress greatly impedes upon digestion. This speaks to the gut/brain axis that we will explore more in depth in our subsequent blog. For now, it is important to recognize the strong interrelationship amongst the body and mind in terms of stress. The gut and brain communicate bi-directionally. Therefore, when stressed is experienced it impedes upon GI functioning and thereby our digestion. Similarly, when our gut functioning is off balanced, this can compromise our stress response and our mood.

Our SeaBD products have vast implications in terms of promoting overall digestive health. They also help to strengthen immunity by supporting a healthy immune response in the body to stress and inflammation. What’s more is that these products also help with gut motility and dysbiosis. These properties speak to the natural yet effective ingredients SeaBD comprises of: such as cannabinoids, the nutrients that make up Sea Buckthorn Oil (antioxidants, essential fatty acids, vitamins and minerals), as well as essential oils.

A number of digestive disorders- such as Inflammatory Bowel Disease (IBD)- encompassing Crohn’s disease and Ulcerative Colitis, in addition to Gastritis and Irritable Bowel Syndrome (IBS) manifest from inflammation, stress/lifestyle factors, as well as insufficient nutrition (1), (2), (3). The natural, yet effective ingredients of our SeaBD products thoroughly address these underlying root causes. Proposed mechanisms for digestive disorders include alterations in gut motility, intestinal permeability, altered intestinal microbiome, compromised immunity and gut/brain interactions (4). SeaBD helps in addressing these mechanisms.

A closer look at the ingredients of Sea Buckthorn Oil in terms of Digestion:

Sea Buckthorn Oil: Vitamins, Minerals, Fatty Acids, & Antioxidant Content

The health benefits of Sea Buckthorn are vast and include significant anti-inflammatory properties, as well as aiding in digestive and immune health. This oil has also been found to improve upon the body’s overall stress response, having vast implications for gut health. The boost in immunity is in large part, to the high flavonoid content of the oil. Sea buckthorn leaf extract acts as an immunosuppressant during the acute phase of inflammation by selectively inhibiting T-cell activation (5).

It is also naturally full of antioxidants that help to protect the body against oxidative stress, as well as inflammation in the body. Specifically, Kaempferol has been indicated to be part of the oil that has the most biologically active properties- exhibiting antioxidant, anti-inflammatory and antimicrobial activities- all of which aide in digestion. Magnesium is also a component of Sea Buckthorn Oil and has strong anti-inflammatory and antioxidant benefits- further aiding in digestion. Vitamin C is also a further component with strong antioxidant properties helping to enhance digestive health. Carotenoids, additionally have vast anti-inflammatory and immune health benefits. Sea Buckthorn Oil also comprises of essential fatty acids which help to reduce inflammation, improve immunity, as well as help the body cope with stress.

The leaves of Sea Buckthorn Oil are used in the treatment of diarrhea and gastrointestinal disorders (6). Overall sea buckthorn offers an excellent source of functional and therapeutic benefit with regards to digestion. The overall effect of sea buckthorn is improvement of gastric emptying, gastric motility and overall gastrointestinal digestive function- all of which are compromised in digestive orders.

Essential Oils. 

Terpenes are organic chemicals constituents of essential oils with various health benefits, such as improving upon sleep and energy levels, as well as enhancing mood health. Terpenes have also been indicated to have anti-inflammatory properties. A closer look at the essential oils in SeaBD demonstrates the therapeutic effects they have on the stress response, dysbiosis, inflammation, immunity and thereby overall digestion. Specifically the antimicrobial agents of a number of essential oils included in SeaBD such as lavender have been found to inhibit the growth of potential pathogens at concentrations that had no effect on the beneficial bacteria of the gut (7).

Cannabinoids

The phytocannabinoids in SeaBD have an imperative role in balancing the body’s natural Endocannabinoid System; reducing inflammation, improving upon digestion, immunity, and the body’s stress response.

Cannabis and its derivatives affect many gastrointestinal processes via the endocannabinoid system (ECS). The ECS influences gastrointestinal homeostasis through anti-inflammatory, and immune modulating effects. Some gastrointestinal disorders might therefore be treated with cannabinoids. In fact a number of those with GI symptoms have found CBD use to be associated with symptom improvement (8).

CBD has been indicated to down-regulate inflammation as well as pain (9). This has been found to be especially effective in patients with IBS (10). Researchers have also found a strong association between cannabinoid receptors and improved GI motility (11). Furthermore, CBD has been shown to modify intestinal microbiome in favorable ways, highlighting its implications for use in the treatment of GI disorders. Several observational studies have noted improvements in both symptoms as well as clinical outcomes in Crohn’s disease- specifically with 21 out of 30 patients- reducing the need for subsequent treatment significantly (12). Similar effects have been noted with Ulcerative Colitis (13).  Finally, a survey of 313 patients with IBD also noted significant findings with CBD for those experiencing abdominal pain, abdominal cramping, joint pain and improvement with GI issues like diarrhea (14, (15).

In conjunction with Perfect Balance Digestive Enzymes- that address key digestion mechanisms that are compromised from nutritional deficiencies, stress, low HCL, enzymes and bile- often leading to these digestive disorders overtime- we can promote healthy digestion in the body from a body/mind approach.

These products not only address stress- that greatly impedes upon digestive and therefore immune health- but also integral parts of the digestive process- that would otherwise lead to inflammation and bacterial overgrowth (compromising our bad to good bacteria ratio). Our digestive enzymes also support healthy detoxification pathways in the body, greatly enhancing elimination and detoxification crucial to strengthening the immune system and overall functioning of the body.

SeaBD helps to improve digestion, significantly reducing stress and inflammation in the body, as well as enhancing overall immunity. This product has numerous implications for mood health- helping the body to manage stress- thereby having an influence on digestion, inflammation and immune health. Finally, Sea BD is rich in nutritional content- further supporting gut health- as well as having significant antioxidant and healing properties in terms of inflammation and immunity.

References:

1.  Nouvenne A. et al. (2018). Digestive disorders and intestinal microbiota. Acta Biomed, 89, 47-51.

2. Mahmoud A. (2020). The relationship between affective disorders and pain: Focusing on the functional gastrointestinal disorders such as irritable bowel syndrome, Annals Series on Biological Sciences, 9, 50-63.

3. Alemaeo C. A et al. (2020). Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders. Allergy Review, 10.

4. Storr MA et al. (2008). The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome. Neurogastroenterol Motil.  20: 857-868

5. Mahmoud A. (2020). The relationship between affective disorders and pain: Focusing on the functional gastrointestinal disorders such as irritable bowel syndrome. Annals Series on Biological Sciences, 99, 50-63.

6. Di Marzo V. (2020). The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders. Dialogues Clinical Neuroscience, 22, 259- 269.

7. Hawrelak J. A. et al. ( 2009). Essential oils in the treatment of intestinal dysbiosis: A preliminary in vitro study. Alternative Medicine Review, 14

8. Gotfried J. et al. (2020). Role of cannabis and its derivatives in gastrointestinal and hepatic disease.  Reviews and Perspectives Review in Basic and Clinical Gastroenterology and Hepatology, 159. 62-80.

9. .Sakin Y.S. et al (2015). The effect of FAAH, MAGL, and dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents. Neurogastroenterol Motil,  27: 936-944

10. .Kikuchi A et al. (2008). Pharmacological evaluation of a novel cannabinoid 2 (CB2) ligand, PF-03550096, in vitro and in vivo by using a rat model of visceral hypersensitivity. J Pharmacol Sci. 106: 219-224

11.Camilleri M et al. (2013). Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits. Am J Physiol Liver Physiol. 304: G553-G560

12.Naftali T. et al. (2011). Treatment of Crohn’s disease with cannabis: an observational study.Isr Med Assoc J, 13: 455-458

13.Kafil T. S. et al. (2018). Cannabis for the treatment of ulcerative colitis. Cochrane Database Syst Rev 2018.  11: CD012954

14.Ts K et al. (2018). Cannabis for the treatment of Crohn's disease.

Cochrane Database Syst Rev. 11: CD012853

15.Naftali T et al. (2013). Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study. Clin Gastroenterol Hepatol. 11: 1276-1280.